you mean remove the ability to see it or the ability to select it? in either case, if you're using pm3 then edit the home.xml file.
if you don't mind the button being there and just disabled then delete the following line from the my programs normal push button section:
<hyperlink>1</hyperlink>
if you want to totally eliminate the button alltogether then do this (bear in mind that the picture of the button itself will still be there, as it's part of the home background picture, but it will have no label and will not be selectable:
delete this section:
<control>
<description>my programs normal push button</description>
<type>button</type>
<id>2</id>
<posx>91</posx>
<posy>231</posy>
<width>14</width>
<height>13</height>
<label>0</label>
<font>special13</font>
<hyperlink>1</hyperlink>
<onleft>98</onleft>
<onright>97</onright>
<onup>9</onup>
<ondown>4</ondown>
<texturefocus>home-focus.gif</texturefocus>
<texturenofocus>-</texturenofocus>
<textoffsetx>30</textoffsetx>
<visible effect="fade" time="200">!player.hasaudio | ![player.hasaudio + system.idletime(60)]</visible>
</control>
change the my pictures normal push button to read
<onup>9</onup>
change the setting normal push button to read
<ondown>4</ondown>
make the same change to my files normal push button
and for the xlink kai conditional button and both submenu buttons below it change it to read:
<onup>4</onup>
<ondown>4</ondown>
make any sense? i think i got myself a bit confused explaining that.